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KMID : 0359920130320020066
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Korean Journal of Nephrology
2013 Volume.32 No. 2 p.66 ~ p.71
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Decreased serum level and increased urinary excretion of vascular endothelial growth factor-C in patients with chronic kidney disease
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Kim Sun-Hee
Jung Yu-Jin
Kang Kyung-Pyo
Lee Sik
Park Sung-Kwang
Lee Ju-Hyung
Kim Nam-Ho
Kim Won
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Abstract
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Background: Interstitial tonicity increases vascular endothelial growth factor-C (VEGF-C), a lymphangiogenic factor in salt-induced hypertension. Therefore, it can be assumed that changes of serum VEGF-C level may be associated with increasing blood pressure. However, there is no report about the changes of serum VEGF-C levels in patients with chronic kidney disease (CKD). The aims of this study were to investigate the changes of serum and urine VEGF-C levels in patients with CKD stage 3?4 and to evaluate the relationship between blood pressure and serum VEGF-C levels in the patients with CKD stage 5 and hemodialysis. Methods: Glomerular filtration rate (GFR) was assessed by the Modification of Diet in Renal Disease equation. Blood pressure and VEGF-C levels (serum and urine) were measured by enzyme-linked immunosorbent assay (ELISA) in nine patients with stage 3?4 CKD, 41 hemodialysis patients, and eight healthy individuals. Results: The median serum level of VEGF-C in patients with stage 3?4 CKD and stage 5 hemodialysis significantly decreased in comparison with healthy individuals. Urinary VEGF-C excretion increased in patients with stage 3?4 CKD compared with healthy control patients. For 41 hemodialysis patients, the serum level of VEGF-C in patients with stage 1 or stage 2 hypertension with hemodialysis did not significantly increase when compared with prehypertension hemodialysis patients. Conclusion: We demonstrated that circulating levels of VEGF-C were decreased in patients with CKD, and the decrease of VEGF-C in patients with stage 3?4 CKD coincided with an increase in the urinary excretion of VEGF-C.
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KEYWORD
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Chronic kidney disease, Hemodialysis, Hypertension, VEGF-C
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